The Efficacy and Acceptability of Antidepressant Medications
Feb 22, 2018
A significant study has been published in The Lancet, titled "Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis." This review included 522 placebo-controlled and head-to-head trials involving 116 477 participants. The authors found that all the antidepressants included in the study were more effective than placebo. They found that some antidepressants had a relatively higher response and lower dropout rate than others, indicating that a balance between efficacy and tolerability is needed to ensure that the benefits of antidepressant medications are maximised.